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ENMD-1068 HCl
CAS No. 789488-77-3
ENMD-1068 HCl ( ENMD1068 | ENMD-1068 | ENMD 1068 | ENMD-1068 HCl | ENMD-1068 hydrochloride )
产品货号. M27875 CAS No. 789488-77-3
ENMD-1068 是 PAR-2 拮抗剂。 ENMD-1068 可抑制小鼠模型中子宫内膜异位症的发展。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 10MG | ￥405 | 有现货 |
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| 25MG | ￥705 | 有现货 |
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| 50MG | ￥1110 | 有现货 |
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| 100MG | 获取报价 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称ENMD-1068 HCl
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述ENMD-1068 是 PAR-2 拮抗剂。 ENMD-1068 可抑制小鼠模型中子宫内膜异位症的发展。
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产品描述ENMD-1068 is a PAR-2 antagonist. ENMD-1068 inhibits the development of endometriosis in a mouse model.
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体外实验Western Blot Analysis Cell Line:Hepatic stellate cells (HSCs) (TGF-β1-stimulated)Concentration:10 mM Incubation Time:24 h Result:Inhibited TGF-β1-induced expression of α-SMA, Col α1(?),Col α1(III), and Smad2/3 C-terminal phosphorylation.
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体内实验Animal Model:ICR mice (8-week-old; CCl4-induced liver fibrosis model).Dosage:25, 50 mg/kg Administration:Intraperitoneal injection; twice per week for 4 weeks Result:Markedly attenuated collagen deposition.Animal Model:Mice with surgically induced endometriosis.Dosage:25, 50 mg/kg Administration:Intraperitoneal injection; single daily for 5 days Result:Reduced the volume of observed lesions in a dose-dependent manner.Inhibited the expression of IL-6 and MCP-1.Decreased the proliferation rate of endometriotic cells and increased the percentage of apoptotic epithelial cells in the lesions.
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同义词ENMD1068 | ENMD-1068 | ENMD 1068 | ENMD-1068 HCl | ENMD-1068 hydrochloride
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通路Proteasome/Ubiquitin
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靶点Serine Protease
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受体PEGs
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研究领域——
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适应症——
化学信息
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CAS Number789488-77-3
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分子量319.87
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分子式C15H30ClN3O2
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纯度>98% (HPLC)
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溶解度——
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SMILESCl.CC(C)CC(=O)N1CCN(CC1)C(=O)CCCCCN
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.
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